Preeclamptic placental stress and over expression of mitochondrial HSP70
نویسندگان
چکیده
منابع مشابه
HSP70 expression and its role in preeclamptic stress.
Preeclampsia, a hypertensive pregnancy-specific disorder, has long been analyzed for its association with cellular stress. It still remains one of the most serious complications of pregnancy. It is a multi-system disorder that affects maternal vascular function and fetal growth. The physiopathology of preeclampsia is still unclear, but an imbalance between reactive oxygen species (ROS) and anti...
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Protein quality control is an important component of survival for all cells. The use of proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally exhibit greater levels of proteotoxic stress than do normal cells, and thus cancer cells tend to be more sensitive to proteasome inhibition. However, this approach has been limited in some cases by toxicity to normal ce...
متن کاملInteraction of mitochondrial presequences with DnaK and mitochondrial hsp70.
Mitochondrial heat shock protein 70 (mt-hsp70) functions as a molecular chaperone in mitochondrial biogenesis. The chaperone in co-operation with its co-proteins acts as a translocation motor pulling the mitochondrial precursor into the matrix. Mt-hsp70s are highly conserved when compared to the bacterial hsp70 homologue, DnaK. Here we have used DnaK as a model to study the interaction of mitoc...
متن کاملPlacental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress in Preeclampsia Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery
Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery and fetal growth retardation. The purpose of this study was to evaluate the expression of heat shock protein 70 (HSP70), both constitutive (HSC70) and induced (HSP70) forms, along with oxidative stress status in the placental tissues of normotensive (control group) and preeclamptic pregnan...
متن کاملBiogenesis of the mitochondrial Hsp70 chaperone
Chaperones mediate protein folding and prevent deleterious protein aggregation in the cell. However, little is known about the biogenesis of chaperones themselves. In this study, we report on the biogenesis of the yeast mitochondrial Hsp70 (mtHsp70) chaperone, which is essential for the functionality of mitochondria. We show in vivo and in organello that mtHsp70 rapidly folds after its import i...
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ژورنال
عنوان ژورنال: Clinical Chemistry and Laboratory Medicine
سال: 2009
ISSN: 1437-4331,1434-6621
DOI: 10.1515/cclm.2009.247